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it all depends on how long you have had residency in your comune.   If you have had residency for more than hal the time you have owned the house then there is no problem.  However, if you turn your house into a second home for letting, and do not buy another prima casa within a year you lose your prima casa agevolazione for good. 

Thanks Ram.  If I understand you correctly we will not have to pay any penalty.  We have no intention of renting the house or buying another.  We may well become resident  again when we are of pensionable age. Steve